Aging and Brain Rejuvenation

Work by our lab, and others, has also demonstrated that the aging central nervous system maintains a certain amount of latent plasticity. Furthermore, work using heterochronic parabiosis - in which the circulatory system of an old and young animal are connected – indicate that this latent plasticity can be tapped into to reverse age-related impairments in neural stem cell function in the old brain. Therefore, a second aim of our research is to begin to elucidate the cellular and molecular mechanisms underlying this latent plasticity and identify key molecules that can promote cognitive enhancements late in life. We combine heterochronic parabiosis and cognitive testing with gain and loss of function experiments to investigate these mechanisms in vivo.