Our lab is interested in understanding what drives regenerative and cognitive impairments in the aging brain, and moreover how the effects of aging can be reversed in the old brain. Our lab is focused on three areas. First, we are looking at how immune-related changes in old blood contribute to impairments in neural stem cell function and associated cognitive functions. Second, we are looking at the contribution of the innate immune system to age-related impairments in synaptic plasticity and cognitive function. Third, we are looking at how exposure to young and exercise blood rejuvenates neural stem cell function, synaptic plasticity and cognitive function in the old brain. Ultimately, our goal is to elucidate cellular and molecular mechanisms that promote brain rejuvenation as a means by which to combat age-related neurodegeneration and cognitive dysfunction.
Our Recent Publications:
So excited to share our latest research on Transferring the Benefits of Exercise to the Aging Brain Through Blood in Science, spearheaded by Alana and Shelly!
Also, a great accompanying Preview from Bill Freeman’s group!
And some highlights in the News:
- Science magazine or listen to the Science Podcast
- The New York Times
- NPR or listen to the research news here.
- UCSF News
Why does neural stem cell number decrease with age? In our newest study, we show that it’s in part due to age-related loss of the post-translational modification O-GlcNAc, and identify a STAT3 O-GlcNAc site critical for NSC fate decisions. Find out more about Buddy & Shelly's paper in the latest issue of PNAS!
Congratulations to Luke Smith for defending his thesis! Find his thesis work on heterochronic hematopoietic stem cell transplants and the role of circulating Cyclophilin A as a pro-aging factor in Aging Cell!
News & Updates:
- COVID-19 Lab Fashion:
Wear a mask and keep your distance!
- How we do science in the time of COVID-19: WFH...