Our lab is interested in understanding what drives regenerative and cognitive impairments in the aging brain, and moreover how the effects of aging can be reversed in the old brain. Our lab is focused on three areas. First, we are looking at how immune-related changes in old blood contribute to impairments in neural stem cell function and associated cognitive functions. Second, we are looking at the contribution of the innate immune system to age-related impairments in synaptic plasticity and cognitive function. Third, we are looking at how exposure to young blood rejuvenates neural stem cell function, synaptic plasticity and cognitive function in the old brain. Ultimately, our goal is to elucidate cellular and molecular mechanisms that promote brain rejuvenation as a means by which to combat age-related neurodegeneration and cognitive dysfunction.
Check out our latest study on β2-microglobulin and Brain Aging
NIH Director's Blog
The Wonderful World of Blood on BBC Four
Radio Interview on Aging and Brain Rejuvenation
Our lab recently changed locations to Health Sciences West 1330. You can check out our new lab space here.
Dr. Villeda participated in a Reddit AMA.
UCSF highlight Brain Rejuvenation Research