Welcome to the Villeda Lab!


Our lab is interested in understanding what drives regenerative and cognitive impairments in the aging brain, and moreover how the effects of aging can be reversed in the old brain. Our lab is focused on three areas. First, we are looking at how immune-related changes in old blood contribute to impairments in neural stem cell function and associated cognitive functions. Second, we are looking at the contribution of the innate immune system to age-related impairments in synaptic plasticity and cognitive function. Third, we are looking at how exposure to young blood rejuvenates neural stem cell function, synaptic plasticity and cognitive function in the old brain. Ultimately, our goal is to elucidate cellular and molecular mechanisms that promote brain rejuvenation as a means by which to combat age-related neurodegeneration and cognitive dysfunction.


In the news:

Check out our latest work on Tet2 as epigenetic regulator of regenerative rejuvenation in the brain!

- Highlight in the UCSF News!


Congrats to Geraldine for receiving a Postdoctoral Transition Award in Aging from the AFAR!


Saul Villeda talks about Aging, rejuvenation and potential business strategies on CNBC!


A vision for the future of UCSF in the recent UCSF Campaign Launch!