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Publications

Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC. 2020. Tolerance Induction and Microglial Engraftment After Fetal Therapy Without Conditioning in Mice With Mucopolysaccharidosis Type VII. Sci Trans Med. Feb 26;12(532):eaay8980. doi: 10.1126/scitranslmed.aay8980. (find it here)

White CW 3rd, Pratt K, Villeda SA. 2019. OPCs on a Diet: A Youthful Serving of Remyelination. Cell Metab. Dec 3;30(6):1004-1006. doi: 10.1016/j.cmet.2019.11.009. (find it here)

Wheatley EG, Albarran E, White CW 3rd, Bieri G, Sanchez-Diaz C, Pratt K, Snethlage CE, Ding JB, Villeda SA. 2019. Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. Curr Biol. 29(20):3359-3369.e4. doi: 10.1016/j.cub.2019.08.003. Epub 2019 Oct 3. (find it here)

Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H. 2019. MANF Regulates Metabolic and Immune Homeostasis in Ageing and Protects Against Liver Damage. Nat Metab. 2019 Feb;1(2):276-290. doi: 10.1038/s42255-018-0023-6. (find it here)

Schroer AB, Horowitz AM, Villeda SA. 2019. Platelets Give a Running Start to Adult Hippocampal Neurogenesis. Stem Cell Reports. 12(4):643-646. doi: 10.1016/j.stemcr.2019.03.007. (find it here)

Geraldine Gontier, Manasi Iyer, Jeremy M. Shea, Gregor Bieri, Elizabeth G. Wheatley, Miguel Ramalho-Santos, Saul Villeda. 2018. Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain. Cell Reports. https://doi.org/10.1016/j.celrep.2018.02.001. (find it here)

Graphical Abstract:
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

Smith LK, White CW 3rd, Villeda SA. 2017. The systemic environment: at the interface of aging and adult neurogenesis. Cell Tissue Res.. Nov 9. doi: 10.1007/s00441-017-2715-8. [Epub ahead of print] Review. (find it on pubmed)

Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, Villeda S, Citri A, Amit I, Schwartz M. 2017. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun.. Sep 28;8(1):717. doi: 10.1038/s41467-017-00769-0. (find it on pubmed)

Horowitz AM, Villeda SA. 2017. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease. F1000Res.. Aug 1;6:1291. doi: 10.12688/f1000research.11437.1. eCollection 2017. Review. (find it on pubmed

Fan X, Wheatley EG, Villeda SA. 2017. Mechanisms of Hippocampal Aging and the Potential for Rejuvenation. Annu Rev Neurosci.. Jul 25;40:251-272. doi: 10.1146/annurev-neuro-072116-031357. Epub 2017 Apr 24. (find it on pubmed)

Udeochu JC, Shea JM, Villeda SA. 2016. Microglia communication: Parallels between aging and Alzheimer's disease. Clin Exp Neuroimmunol.. May;7(2):114-125. Epub 2016 May 3. Review. (find it on pubmed)

Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T. 2016. Preclinical Assessment of Young Blood Plasma for Alzheimer Disease. JAMA Neurol. Nov 1;73(11):1325-1333. doi: 10.1001/jamaneurol.2016.3185. (find it on pubmed)

Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG.. 2016. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. Aug 3;5. pii: e18156. doi: 10.7554/eLife.18156. (find it on pubmed)

M. Armanios, R. de Cabo, J. Mannick, L. Partridge, J. van Deursen, S.A. Villeda. 2015. Translational strategies in aging and age-related disease. Nature Medicine. 21(12):1395-9. doi: 10.1038/nm.4004. (find it on pubmed

G. Gontier, K. Lin, S.A. Villeda. 2015. Fat Chance for Neural Stem Cells in Alzheimer's Disease. Cell Stem Cell. 17(4):373-4. doi: 10.1016/j.stem.2015.09.006. (find it on pubmed)

L.K. Smith, Y. He, J-S. Park, G. Bieri, C.E. Snethlage, K. Lin, G. Gontier, R. Wabl, K.E. Plambeck, J. Udeochu, E.G. Wheatley, J. Bouchard, A. Eggel, R. Narasimha, J.L. Grant, J. Luo, T. Wyss-Coray, S.A. Villeda. 2015. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nature Medicine. 21(8):932-7. doi: 10.1038/nm.3898. Epub 2015 Jul 6. (find it on pubmed)

J. Bouchard, S.A. Villeda. 2014. Aging and Brain Rejuvenation as Systemic Events. J. Neurochem. 2014 132(1):5-19. doi: 10.1111/jnc.12969. Epub 2014 Dec 5. (find it on pubmed

S.A Villeda, K.E. Plambeck, J. Middeldorp, J.M. Castellano, K.I. Mosher, J. Luo, L.K. Smith, G. Bieri, K. Lin, D. Berdnik, R. Wabl, J. Udeochu, E.G. Wheatley, B. Zou, D.A. Simmons, X.S. Xie, F.M. Longo, T Wyss-Coray. 2014. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4. (find it on pubmed)

Y. He, H. Zhang, A. Yung, S.A. Villeda, P.A. Jaeger, O. Olayiwola, N. Fainberg, T. Wyss-Coray. 2014. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis. Nat Neurosci. 17(7):943-52. doi: 10.1038/nn.3732. (find it on pubmed) 

J. Luo, A. Nguyen, S.A. Villeda, H. Zhang, Z. Ding, D. Lindsey, G. Bieri, J.M. Castellano, G.S. Beaupre, T. Wyss-Coray. 2014. Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury. Front Neurol. 5:12. doi: 10.3389/fneur.2014.00012. eCollection 2014. (find it on pubmed)

J. Luo, F. Elwood, M. Britschgi, S. Villeda, H. Zhang, Z. Ding, L. Zhu, H. Alabsi, R. Getachew, R. Narasimhan, N. Fainberg, ML. James, G. Wong, J. Relton, SS. Gambhir, JW. Pollard, T. Wyss-Coray. 2013. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 210(1):157-72. doi: 10.1084/jem.20120412. (find it on pubmed) 

S.A. Villeda,  T. Wyss-Coray. 2012. The Circulatory Systemic Environment as a Modulator of Neurogenesis and Brain Aging. Autoimmune Rev. doi:pii: S1568-9972(12)00272-8. 10.1016/j.autrev.2012.10.014. (find it on pubmed)

S.A. Villeda, J. Luo, K.I. Mosher, B. Zou, M. Britschgi, G. Bieri, T.M. Stan, N. Fainberg,  Z. Ding, A. Eggel, K.M. Lucin, E. Czirr, J-S. Park, S. Doupres-Couillard, L. Aigner, G. Li, E.R. Peskind, J.A. Kaye, J.F. Quinn, D.R. Galasko, X.S. Xie, T.A. Rando, and T. Wyss-Coray. 2011. The aging systemic milieu negatively regulate neurogenesis and cognitive function. Nature. 477(7362):90-4. doi: 10.1038/nature10357. (find it on pubmed)

M. Moriyama, T. Fukuhara, M. Britschgi, Y. He, R. Narasimhan, S. Villeda, H. Molina, B.T Huber, M. Holers, and T. Wyss-Coray. 2011. Complement receptor CR2/CD21 is expressed by neuronal progenitor cells and regulates adult hippocampal neurogenesis. Journal of Neuroscience. 31(11):3981-3989. (find it on pubmed)

V.M. Renault, V.A. Rafalski, A. Morgan, D.A. Salih, J.O. Brett, A.E. Webb, S.A. Villeda, P.U. Thekkat, C. Guillerey, N.C.Denko, T.D. Palmer, A.J. Butte, and A. Brunet. 2009. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 5(5):527-39. (find it on pubmed)

S. Villeda and T. Wyss-Coray. 2008. Microglia – a wrench in the running wheel? Neuron. 59(4): 527-9.  (find it on pubmed)

S.A. Villeda, A. Akopians, A.H. Babayan, A.I. Basbaum and P.E. Phelps. 2006. Absence of Reelin results in altered nociception and aberrant neuronal positioning of the dorsal spinal cord. Neuroscience. 139: 1385-1396. (find it on pubmed)

M.D. Kubasak, R. Brooks, S. Chen, S.A. Villeda, and P.E. Phelps. 2004. Developmental distribution of Reelin-positive cells and their secreted product in the rodent spinal cord. J. Comp. Neurol. 486 (2): 165-78. (find it on pubmed)