Molecular Mechanisms of Brain Rejuvenation

Cognition
Regenerative Capacity
Synaptic Plasticity
Neuroinflammation

Aging drives cognitive impairments and susceptibility to dementia-related neurodegenerative diseases, including Alzheimer’s disease. We, and others, have shown that systemic interventions such as heterochronic parabiosis (in which the circulatory systems of young and old animals are joined), administration of young blood plasma, exercise, or administration of exercise-induced blood factors can functionally rejuvenate the aged brain. Additionally, systemic intervention studies have revealed an age-dependent bi-directionality in the influence of the systemic environment indicating both pro-youthful and pro-aging circulating factors in blood. These findings posit blood-based strategies targeting circulating factors as exciting new approaches to promote brain rejuvenation.

Our lab is interested in understanding what drives functional and cognitive impairments in the aging brain, and importantly how the effects of aging can be reversed in the old brain through systemic interventions. Specifically, we are investigating the following hallmarks of brain aging in the adult hippocampus:

  1. Decreased Regenerative Capacity
  2. Impaired Synaptic Plasticity
  3. Increased Neuroinflammation

Our goal is to elucidate cellular and molecular mechanisms that can be targeted for novel therapies to prevent, ameliorate and reverse dementia-related neurodegenerative diseases in the elderly.