Publications

Complete List of Publications Here 

2021

K. Lin, G. Bieri, Geraldine Gontier, S. Muller, L.K. Smith, C.E. Snethlage, C.W. White III, S. Maybury-Lewis, and S.A. Villeda. MHC Class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signalingPLOS Biology19(6): e3001311.  

T.T. Ho, P.V. Dellorusso, E.V. Verovskaya, S.T. Bakker, J. Flach, L.K. Smith, P.B. Ventura, O.M. Lansinger, A. Herault, S.Y. Zhang, Y-A. Kang, S.A. Villeda, and E. Passegue. Aged hematopoietic stem cells are refractory to systemic interventionsJournal of Experimental Medicine218(7):e20210223

 

2020

A.M. Horowitz, X. Fan, G. Bieri, L.K. Smith, C.I. Sanchez-Diaz, A.B. Schroer, G. Gontier, K.B. Casaletto, J.H. Kramer, K.E. Williams, and S.A. Villeda. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brainScience369(6500):167-173.

  • Insights: Exercising your mind. Science. 369(6500):144-145.
  • Research Highlight: Blood from fit mice bestows brain benefits of exercise. Nature. 583:335.
  • Comment: A new player in the beneficial effects of exercise on the aged brain. Signal Transduct Target Ther. 5:184.

C.W. White III, X. Fan, J.C. Maynard, E.G. Wheatley, G. Bieri, J. Couthois, A.L. Burlingame, and S.A. Villeda. Age-related loss of neural stem cell O-GlcNAc promotes a glial cell fate switch through STAT3 activationProceeding of the National Academy of Sciences USA177(36):22214-22214.  

L.K. Smith, E. Verovskaya, G. Bieri, A.M. Horowitz, S.N.I. von Ungern-Sternberg, K. Lin, P. Seizer, E. Passegue, and S.A. Villeda. The aged hematopoietic system promotes hippocampal-dependent cognitive declineAging Cell19(8):e13192.  

D. Brigger, C. Riether, Robin van Brummelen, K.I. Mosher, A. Shiu, Z. Ding, H. Yousef, J.M. Castellano, D. Storni, N. Graff-Radford, M. Britschgi, D. Grandgirard, M. Siegrist, N. Moullan, W. Hofstetter, S.L. Leib, P.M. Villiger, J. Auwerx, S.A. Villeda, T. Wyss-Coray, M. Noti, and A. Eggel. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old ageNature Metabolism2(8):688-702.

Q-H. Nguyen, R.G. Witt, B. Wang, C. Eikani, J. Shea, L. Smith, G. Boyle, J. Cadaoas, R. Sper, J.D. MacKenzie, S. Villeda and T.C. MacKenzie. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis Type VIIScience Translational Medicine. 12(532):8980.

J.M Shea and S.A. Villeda. Dampening the power of the brain – when aging meets cognitionJournal of Gerontology: Biological Sciences DOI:10.1093/Gerona/glaa170.

 

2019

E.G. Wheatley, E. Albarran, C.W. White III, G. Bieri, C.I. Sanchez-Diaz, K. Pratt, C.E. Snethlage, J.B. Ding, and S.A. Villeda. Neuronal O-GlcNAcylation improves cognitive function in the aged mouse brainCurrent Biology29(20):3359-3369.

C. Schneider, J. Lee, S. Koga, R.R. Ricardo-Gonzalez, J.C. Nussbaum, L.K. Smith, S.A. Villeda, H.E. Liang and R.M. Locksley.  Tissue-resident group 2 innate lymphoid cells differentiate by layered ontogeny and in situ perinatal priming. Immunity. 7613(19):30199-2. 

P. Sousa-Victor, J. Neves, W. Cedron-Craft, P.B. Ventura, C-Y. Liao, R.R. Riley, I. Soifer, N. van Bruggen, G.A. Kolumam, S.A. Villeda, D.A. Lamba and H. Jasper. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism. 1(2):276-290.

S.N. Austad, M.A. Wood, S.A Villeda, J.L. Voss, A. Sahay and M. Albert. Innovative approaches in cognitive aging. Neurobiology of Aging4580(19):30127-7.  

A.B. Schroer, A.M. Horowitz and S.A Villeda. Platelets give a running start to adult hippocampal neurogenesis. Stem Cell Reports12(4):643-646.  

C.W. White 3rd, K. Pratt, S.A. Villeda. OPCs on a Diet: A Youthful Serving of Remyelination. Cell Metabolism. 30(6):1004-1006. 

 

2018

G. Gontier, M. Iyer, J.M. Shea, G. Bieri, E.G. Wheatley, M. Ramalho-Santos, and S.A. Villeda. Tet2 rescues age-related regenerative decline and enhances cognitive function in the adult mouse brainCell Reports22(8):1974-1981.

G.B. Bieri. K.M. Lucin, C.E. O’Brien, S.A. Villeda, and T. Wyss-Coray.  Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Molecular Neurodegeneration13(1):68.

L.K. Smith, C.W. White and S.A Villeda. The systemic environment: at the interface of aging and adult neurogenesis. Cell Tissue Res. 371(1):105-113.  

 

2017

A. Deczkowska, O. Matcovitch-Natan, A. Tsitsou-Kampeli, S. Ben-Hamo, R. Dvir-Szternfeld, A. Spinrad, O. Singer, E. David, D.R. Winter, L.K. Smith, A. Kertser, K. Baruch, N. Rosenzweig, A. Terem, M. Prinz, S. Villeda, A. Citri, I. Amit, and M. Schwartz. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an INF-I-dependent manner. Nature Communications. 8(1):717. 

X. Fan, E.G. Wheatley and S.A Villeda. Mechanisms of hippocampal aging and the potential for rejuvenation. Annual Review of Neuroscience40: 251-271.  

A.M. Horowitz and S.A Villeda. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease. F1000 ResearchDOI: 10.1007/s00441-017-2715-8.

 

2016

Y. Zhang, T.L. Roth, E.E. Gray, H. Chen, L.B. Rodda, Y. Liang, P. Ventura, S. Villeda, P.R. Crocker, and J.G. Cyster. Mechanisms of innate-like lymphocyte surveillance of the subcapsular sinus to provide lymph node barrier immunity. eLifeDOI: 10.7554/3Life.18156  

J. Middeldorp, B. Lehallier, S.A. Villeda, S. Miedema, E. Evans, E. Czirr, H. Zhang, J. Luo, T. Stan, K. Mosher, E. Masliah and T. Wyss-Coray. Pre-clinical assessment of young plasma for Alzheimer’s disease. JAMA Neurology. 73(11):1325-1333.

J. U. Udeochu, J. M. Shea, and S.A. Villeda. Microglia communication: Parallels between aging and Alzheimer’s disease. Clinical and Experimental Neuroimmunology7(2):114-125.  

 

2015

L.K. Smith, Y.B. He, J.S. Park, G. Bieri, C. Snethlage, K. Lin, G. Gontier, R. Wabl, K. Plambeck, J. Udeochu, E.G. Wheatley, J. Bouchard, A. Eggel, R. Narasimha, J.L. Grant, J. Lou, T. Wyss-Coray and S.A. Villedaβ2-Microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesisNature Medicine21(8):932-37. 

  • News and Views: Breaking bad blood. Nature Medicine. 21(8):844-45
  • Highlight: ‘Old-age protein’ may cause memory loss. ScienceNow. AAAS; 2015

M. Armanios, R. De Cabo, J. Mannick, L. Partridge, J. Van Deursen, and S. Villeda. Translational strategies in aging and age-related disease. Nature Medicine. 21(12):1-5.  

G. Gontier, K. Lin and S.A. Villeda. Fat chance for neural stem cells in Alzheimer’s disease. Cell Stem Cell. 17(4):373-374.  

 

2014

S.A. Villeda*, K. Plambeck, J. Middeldorp, J.M. Castellano, K.I. Mosher, J. Luo, L.K. Smith, G. Bieri, K. Lin, D. Berdnik, R. Wabl, J. Udeochu, E.G. Wheatley, B. Zou, D. Simmons, X.S. Xie, F. Longo, T. Wyss-Coray*. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in miceNature Medicine. 20(6):659-63 *co-corresponding author

  • News and Views: Young blood rejuvenates old brains. Nature Medicine. 20(6):582-83
  • Highlight: Young Blood. New England Journal of Medicine371(6):573-5
  • Highlight: Blood-derived rejuvenation. Nat. Rev. Neurosci. 15:352
  • Highlight: Could young blood combat age-related cognitive decline. Nat. Rev. Neurol. 
  • Rejuvenation: It’s in our blood. Cell Metabolism20(1):2-4
  • Highlight: Young blood renews old mice. ScienceNow. AAAS; 2014

J. Bouchard & S.A. Villeda. Aging and Brain Rejuvenation as Systemic Events. Journal of Neurochemistry. 132(1):5-19.

 

2011

S.A. Villeda, J. Luo, K.I. Mosher, B. Zou, M. Britschgi, G. Bieri, T.M. Stan, N. Fainberg,  Z. Ding, A. Eggel, K.M. Lucin, E. Czirr, J-S. Park, S. Doupres-Couillard, L. Aigner, G. Li, E.R. Peskind, J.A. Kaye, J.F. Quinn, D.R. Galasko, X.S. Xie, T.A. Rando, and T. Wyss-Coray. The aging systemic milieu negatively regulates neurogenesis and cognitive functionNature. 477(7362):90-4  

  • News and Views: Ageing: Blood Ties. Nature. 477(7362):41-2
  • Highlight: Ageing, it’s in the blood. Nat. Rev. Neurosci. 12(10):547
  • Highlight: The Brain’s Fountain of Youth. ScienceNow. AAAS; 2011