Publications

M.E. Stevenson*, G. Bieri*, R. Kaletsky, J. St. Agne, L. Remesal , K.J.B. Pratt, S. Zhou, Y. Weng, C.T. Murphy^#, and S.A. Villeda^#. Neuronal activation of Gaq EGL-30/GNAQ late in life rejuvenates cognition across species. Cell Reports. DOI:10.1016/j.celrep.2023.113151. ^#co-corresponding author

A.B. Schroer*#, P.B. Ventura*, J. Sucharov Costa, R. Misra, M.K.K. Chui, G. Bieri, A.M. Horowitz, L.K. Smith, K. Encabo, I. Tenggara, J. Couthouis, J.D. Gross, J.M. Chan, A. Luke, and S.A. Villeda#. Platelet factors attenuate inflammation and rescue cognition in aging. Nature. DOI:10.1038/s41586-023-06436-3.

• Research Highlight: Older mouse brains rejuvenated by protein found in young blood. Nature. 
• Research Highlight: A platelet-derived factor protects teh ageing brain. Nat. Rev. Immunol. 

G. Bieri, A.B. Schroer and S.A. Villeda. Blood to brain communication in aging and rejuvenation. Nature Neuroscience. 26(3):379-393.

O. Leiter, D. Brici, S.J. Fletcher, X.L.H. Yong, J. Widago, M. Matigian, A.B. Schroer, G. Bieri, D.G. Blackmore, P.F. Bartlett, S.A. Villeda, and T.L. Walker. Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nature Communications. DOI:10.1038/s41467-023-39873-9.

C. Park, O. Hahn, S. Gupta, A.J. Moreno, B. Kedir, D. Wang, S.A. Villeda, T. Wyss-Coray and D.B. Dubal. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. Nature Aging.

J.M. Braz, K. Hamel, V. Craik, S. Rodriguez-Rosado, K. Bhardwaj, M. Jewell, G. Bieri, S.A. Villeda, and A.I. Basbaum. Pain and itch processing in aged mice. Journal of Pain. DOI: 10.1016/j.jpain.2023.07.018. 

S. Villeda, H. Brown-Borg, and R. Anderson. Neurobiology of Aging: New Insights from Across the Research Spectrum. Journal of Gerontology: Biological Sciences. 78(6):869-871

K.J.B. Pratt*, J.M. Shea*, L. Remesal-Gomez, G. Bieri, L.K. Smith, J. Couthois, C.P. Chen, I.R. Roy, G. Gontier^# and S.A. Villeda^#. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function. Cell Reports. 41(6):111612 

L. Chow, R. Gerszten, J. Taylor, B. Pedersen, H. van Praag, S. Trappe, M. Fabbraio, Z. Galis, J. Haus, I. Lanza, C. Lavie, C-H. Lee, A. Lucia, C. Moro, A. Pandley, J. Robbins, K. Stanford, A. Thackray, S. Villeda, M. Watt, A. Xia, J. Zierath, B. Goodpaster, and M. Snyder. Exerkines in health, resilience and disease. Nature Reviews Endocrinology. 18(5):273-289.

D. Yu, T. Li, J-C., Delpech, B. Zhu, P. Kishore, T. Koshi, R. Luo, K.J.B. Pratt, G. Popova, T.J. Nowakowski, S.A. Villeda, and X. Piao. Microglial GPR56 is the molecular target of meternal immune activation-induced parbalbumin-positive interneuron deficits. Science Advances. 8(18):eabm2545.

K. Lin, G. Bieri, Geraldine Gontier, S. Muller, L.K. Smith, C.E. Snethlage, C.W. White III, S. Maybury-Lewis, and S.A. Villeda. MHC Class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling. PLOS Biology. 19(6): e3001311.  

T.T. Ho, P.V. Dellorusso, E.V. Verovskaya, S.T. Bakker, J. Flach, L.K. Smith, P.B. Ventura, O.M. Lansinger, A. Herault, S.Y. Zhang, Y-A. Kang, S.A. Villeda, and E. Passegue. Aged hematopoietic stem cells are refractory to systemic interventions. Journal of Experimental Medicine. 218(7):e20210223

A.M. Horowitz, X. Fan, G. Bieri, L.K. Smith, C.I. Sanchez-Diaz, A.B. Schroer, G. Gontier, K.B. Casaletto, J.H. Kramer, K.E. Williams, and S.A. Villeda. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Science. 369(6500):167-173.

• Insights: Exercising your mind. Science. 369(6500):144-145.
• Research Highlight: Blood from fit mice bestows brain benefits of exercise. Nature. 583:335.
• Comment: A new player in the beneficial effects of exercise on the aged brain. Signal Transduct Target Ther. 5:184.

C.W. White III, X. Fan, J.C. Maynard, E.G. Wheatley, G. Bieri, J. Couthois, A.L. Burlingame, and S.A. Villeda. Age-related loss of neural stem cell O-GlcNAc promotes a glial cell fate switch through STAT3 activation. Proceeding of the National Academy of Sciences USA. 177(36):22214-22214.  

L.K. Smith, E. Verovskaya, G. Bieri, A.M. Horowitz, S.N.I. von Ungern-Sternberg, K. Lin, P. Seizer, E. Passegue, and S.A. Villeda. The aged hematopoietic system promotes hippocampal-dependent cognitive decline. Aging Cell. 19(8):e13192.  

D. Brigger, C. Riether, Robin van Brummelen, K.I. Mosher, A. Shiu, Z. Ding, H. Yousef, J.M. Castellano, D. Storni, N. Graff-Radford, M. Britschgi, D. Grandgirard, M. Siegrist, N. Moullan, W. Hofstetter, S.L. Leib, P.M. Villiger, J. Auwerx, S.A. Villeda, T. Wyss-Coray, M. Noti, and A. Eggel. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature Metabolism. 2(8):688-702.

Q-H. Nguyen, R.G. Witt, B. Wang, C. Eikani, J. Shea, L. Smith, G. Boyle, J. Cadaoas, R. Sper, J.D. MacKenzie, S. Villeda and T.C. MacKenzie. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis Type VII. Science Translational Medicine. 12(532):8980.

J.M Shea and S.A. Villeda. Dampening the power of the brain – when aging meets cognition. Journal of Gerontology: Biological Sciences DOI:10.1093/Gerona/glaa170.

E.G. Wheatley, E. Albarran, C.W. White III, G. Bieri, C.I. Sanchez-Diaz, K. Pratt, C.E. Snethlage, J.B. Ding, and S.A. Villeda. Neuronal O-GlcNAcylation improves cognitive function in the aged mouse brain. Current Biology. 29(20):3359-3369.

C. Schneider, J. Lee, S. Koga, R.R. Ricardo-Gonzalez, J.C. Nussbaum, L.K. Smith, S.A. Villeda, H.E. Liang and R.M. Locksley.  Tissue-resident group 2 innate lymphoid cells differentiate by layered ontogeny and in situ perinatal priming. Immunity. 7613(19):30199-2. 

P. Sousa-Victor, J. Neves, W. Cedron-Craft, P.B. Ventura, C-Y. Liao, R.R. Riley, I. Soifer, N. van Bruggen, G.A. Kolumam, S.A. Villeda, D.A. Lamba and H. Jasper. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism. 1(2):276-290.

S.N. Austad, M.A. Wood, S.A Villeda, J.L. Voss, A. Sahay and M. Albert. Innovative approaches in cognitive aging. Neurobiology of Aging. 4580(19):30127-7.  

A.B. Schroer, A.M. Horowitz and S.A Villeda. Platelets give a running start to adult hippocampal neurogenesis. Stem Cell Reports. 12(4):643-646.  

C.W. White 3^rd, K. Pratt, S.A. Villeda. OPCs on a Diet: A Youthful Serving of Remyelination. Cell Metabolism. 30(6):1004-1006. 

G. Gontier, M. Iyer, J.M. Shea, G. Bieri, E.G. Wheatley, M. Ramalho-Santos, and S.A. Villeda. Tet2 rescues age-related regenerative decline and enhances cognitive function in the adult mouse brain. Cell Reports. 22(8):1974-1981.

G.B. Bieri. K.M. Lucin, C.E. O’Brien, S.A. Villeda, and T. Wyss-Coray.  Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Molecular Neurodegeneration. 13(1):68.

L.K. Smith, C.W. White and S.A Villeda. The systemic environment: at the interface of aging and adult neurogenesis. Cell Tissue Res. 371(1):105-113.  

A. Deczkowska, O. Matcovitch-Natan, A. Tsitsou-Kampeli, S. Ben-Hamo, R. Dvir-Szternfeld, A. Spinrad, O. Singer, E. David, D.R. Winter, L.K. Smith, A. Kertser, K. Baruch, N. Rosenzweig, A. Terem, M. Prinz, S. Villeda, A. Citri, I. Amit, and M. Schwartz. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an INF-I-dependent manner. Nature Communications. 8(1):717. 

X. Fan, E.G. Wheatley and S.A Villeda. Mechanisms of hippocampal aging and the potential for rejuvenation. Annual Review of Neuroscience. 40: 251-271.  

A.M. Horowitz and S.A Villeda. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease. F1000 Research. DOI: 10.1007/s00441-017-2715-8.

Y. Zhang, T.L. Roth, E.E. Gray, H. Chen, L.B. Rodda, Y. Liang, P. Ventura, S. Villeda, P.R. Crocker, and J.G. Cyster. Mechanisms of innate-like lymphocyte surveillance of the subcapsular sinus to provide lymph node barrier immunity. eLife. DOI: 10.7554/3Life.18156  

J. Middeldorp, B. Lehallier, S.A. Villeda, S. Miedema, E. Evans, E. Czirr, H. Zhang, J. Luo, T. Stan, K. Mosher, E. Masliah and T. Wyss-Coray. Pre-clinical assessment of young plasma for Alzheimer’s disease. JAMA Neurology. 73(11):1325-1333.

J. U. Udeochu, J. M. Shea, and S.A. Villeda. Microglia communication: Parallels between aging and Alzheimer’s disease. Clinical and Experimental Neuroimmunology. 7(2):114-125.  

L.K. Smith, Y.B. He, J.S. Park, G. Bieri, C. Snethlage, K. Lin, G. Gontier, R. Wabl, K. Plambeck, J. Udeochu, E.G. Wheatley, J. Bouchard, A. Eggel, R. Narasimha, J.L. Grant, J. Lou, T. Wyss-Coray and S.A. Villeda. β2-Microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nature Medicine. 21(8):932-37. 

• News and Views: Breaking bad blood. Nature Medicine. 21(8):844-45
• Highlight: ‘Old-age protein’ may cause memory loss. ScienceNow. AAAS; 2015

M. Armanios, R. De Cabo, J. Mannick, L. Partridge, J. Van Deursen, and S. Villeda. Translational strategies in aging and age-related disease. Nature Medicine. 21(12):1-5.  

G. Gontier, K. Lin and S.A. Villeda. Fat chance for neural stem cells in Alzheimer’s disease. Cell Stem Cell. 17(4):373-374.  

S.A. Villeda*, K. Plambeck, J. Middeldorp, J.M. Castellano, K.I. Mosher, J. Luo, L.K. Smith, G. Bieri, K. Lin, D. Berdnik, R. Wabl, J. Udeochu, E.G. Wheatley, B. Zou, D. Simmons, X.S. Xie, F. Longo, T. Wyss-Coray*. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20(6):659-63 *co-corresponding author

• News and Views: Young blood rejuvenates old brains. Nature Medicine. 20(6):582-83
• Highlight: Young Blood. New England Journal of Medicine. 371(6):573-5
• Highlight: Blood-derived rejuvenation. Nat. Rev. Neurosci. 15:352
• Highlight: Could young blood combat age-related cognitive decline. Nat. Rev. Neurol. 
• Rejuvenation: It’s in our blood. Cell Metabolism. 20(1):2-4
• Highlight: Young blood renews old mice. ScienceNow. AAAS; 2014

J. Bouchard & S.A. Villeda. Aging and Brain Rejuvenation as Systemic Events. Journal of Neurochemistry. 132(1):5-19.

S.A. Villeda, J. Luo, K.I. Mosher, B. Zou, M. Britschgi, G. Bieri, T.M. Stan, N. Fainberg,  Z. Ding, A. Eggel, K.M. Lucin, E. Czirr, J-S. Park, S. Doupres-Couillard, L. Aigner, G. Li, E.R. Peskind, J.A. Kaye, J.F. Quinn, D.R. Galasko, X.S. Xie, T.A. Rando, and T. Wyss-Coray. The aging systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 477(7362):90-4  

• News and Views: Ageing: Blood Ties. Nature. 477(7362):41-2
• Highlight: Ageing, it’s in the blood. Nat. Rev. Neurosci. 12(10):547
• Highlight: The Brain’s Fountain of Youth. ScienceNow. AAAS; 2011